High sensitivity of CAP-FEIA rVes v 5 and rVes v 1 for diagnosis of Vespula venom allergy

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Specific allergen concentration of WHO and FDA reference preparations measured using a multiple allergen standard.

of diagnostic tests based on recombinant yellow jacket venom allergens. Nevertheless, rVes v 5 and rVes v 1 had missed 8% of subjects with established allergy. Testing for rVes v 2b added only a minor contribution to diagnostic sensitivity. Primarily, 3 allergens were recognized as responsible for Vespula venom allergy, beyond Ves v 5 and Ves v 1, also Ves v 2, which occurs in isoforms. Recentl...

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Component-resolved diagnosis in vespid venom-allergic individuals.

BACKGROUND Hymenoptera venom-allergic patients frequently present multiple sensitisations. OBJECTIVES To define the allergic profile by components in wasp allergic patients. To study the usefulness of specific IgE to components in cases of double sensitisation. MATERIALS AND METHODS Wasp allergic patients who needed Polistes and/or Vespula venom immunotherapy were included. Before immunothe...

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Down-Regulation of FcεRI-Mediated CD63 Basophil Response during Short-Term VIT Determined Venom-Nonspecific Desensitization

BACKGROUND We recently showed a desensitization of FcεRI-mediated basophil response after short-term VIT. Our aim was to evaluate the allergen specificity of this desensitization. METHODS In 11 Hymenoptera-venom double positive subjects, basophil threshold sensitivity (CD-sens) to anti-FcεRI, honeybee, and Vespula venom was assessed at the beginning and just before the first maintenance dose ...

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ژورنال

عنوان ژورنال: Journal of Allergy and Clinical Immunology

سال: 2012

ISSN: 0091-6749

DOI: 10.1016/j.jaci.2011.12.975